Reactome | Activated FGFR2 binds FRS3

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Activated FGFR2 binds FRS3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10967528
displayName	Activated FGFR2 binds FRS3
eventOf	[Pathway:R-CEL-5654700] FRS-mediated FGFR2 signaling - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-5654605] Activated FGFR2 phosphorylates FRS3 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-5654603] Activated FGFR2 binds FRS3 - Homo sapiens
input	[DefinedSet:R-CEL-5654152] Activated FGFR2 [plasma membrane] [EntityWithAccessionedSequence:R-CEL-191482] rog-1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR2 binds FRS3
output	[Complex:R-CEL-5654277] Activated FGFR2:FRS3 [plasma membrane]
precedingEvent	[Reaction:R-CEL-190408] Autocatalytic phosphorylation of FGFR2b - Caenorhabditis elegans [Reaction:R-CEL-190413] Autocatalytic phosphorylation of FGFR2c - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-5654603
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-5654700] FRS-mediated FGFR2 signaling
(precedingEvent)	[Reaction:R-CEL-5654605] Activated FGFR2 phosphorylates FRS3
(inferredTo)	[Reaction:R-HSA-5654603] Activated FGFR2 binds FRS3