Reactome | Activated FGFR1:p-FRS bind to PPTN11

Schema > Reaction > Entries

Activated FGFR1:p-FRS bind to PPTN11 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5654583] Rothfels, Karen, 2014-12-03
dbId	5654584
deleted	[Deleted:5655565] Deletion of instance: 190358
displayName	Activated FGFR1:p-FRS bind to PPTN11
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654693] FRS-mediated FGFR1 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654587] Activated FGFR1:p-FRS phosphorylates PPTN11 - Homo sapiens
input	[DefinedSet:R-HSA-5654262] Activated FGFR1:p-FRS [plasma membrane] [EntityWithAccessionedSequence:R-HSA-162563] PTPN11 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated FGFR1:p-FRS bind to PPTN11
orthologousEvent	[Reaction:R-SSC-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Sus scrofa [Reaction:R-GGA-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Gallus gallus [Reaction:R-XTR-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Xenopus tropicalis [Reaction:R-BTA-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Bos taurus [Reaction:R-CFA-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Canis familiaris [Reaction:R-RNO-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Rattus norvegicus [Reaction:R-MMU-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Mus musculus
output	[Complex:R-HSA-5654268] Activated FGFR1:p-FRS:PTPN11 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654575] Activated FGFR1 phosphorylates FRS2 - Homo sapiens [Reaction:R-HSA-5654578] Activated FGFR1 phosphorylates FRS3 - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654584
summation	[Summation:1268151] p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.

Referrals

(replacementInstances)	[Deleted:5655565] Deletion of instance: 190358
(hasEvent)	[Pathway:R-HSA-5654693] FRS-mediated FGFR1 signaling
(precedingEvent)	[Reaction:R-HSA-5654587] Activated FGFR1:p-FRS phosphorylates PPTN11