Activated FGFR1:p-FRS bind to PPTN11

Stable Identifier
R-HSA-5654584
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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p-FRS2 has two PPTN11/SHP2-binding sites at pY436 and pY471.

Literature References
PubMed ID Title Journal Year
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Agazie, YM, Movilla, N, Ischenko, I, Hayman, MJ

Oncogene 2003
9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

Hadari, YR, Kouhara, H, Lax, I, Schlessinger, J

Mol Cell Biol 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created