Reactome | Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Stable Identifier

R-HSA-5654426

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Downstream signaling of activated FGFR4 (Homo sapiens)
        
        SHC-mediated cascade:FGFR4 (Homo sapiens)
        
        Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)

General

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Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

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SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.

Literature References

PubMed ID	Title	Journal	Year
8493579	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 Chardin, P, Camonis, JH, Gale, NW, Van Aelst, L, Schlessinger, J, Wigler, MH, Bar-Sagi, D	Science	1993