Reactome | Phospholipase C-mediated cascade: FGFR1

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Phospholipase C-mediated cascade: FGFR1 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654218] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	5654219
deleted	[Deleted:5655578] Deletion of instance: 190347
displayName	Phospholipase C-mediated cascade: FGFR1
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654687] Downstream signaling of activated FGFR1 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5654167] Activated FGFR1 binds PLCG1 - Homo sapiens [Reaction:R-HSA-5654149] Activated FGFR1 phosphorylates PLCG1 - Homo sapiens [Reaction:R-HSA-5654165] p-4Y-PLCG1 dissociates from activated FGFR1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-10-05
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors [LiteratureReference:191025] A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Phospholipase C-mediated cascade: FGFR1
orthologousEvent	[Pathway:R-SSC-5654219] Phospholipase C-mediated cascade: FGFR1 - Sus scrofa [Pathway:R-CEL-5654219] Phospholipase C-mediated cascade: FGFR1 - Caenorhabditis elegans [Pathway:R-DME-5654219] Phospholipase C-mediated cascade: FGFR1 - Drosophila melanogaster [Pathway:R-GGA-5654219] Phospholipase C-mediated cascade: FGFR1 - Gallus gallus [Pathway:R-XTR-5654219] Phospholipase C-mediated cascade: FGFR1 - Xenopus tropicalis [Pathway:R-DRE-5654219] Phospholipase C-mediated cascade: FGFR1 - Danio rerio [Pathway:R-BTA-5654219] Phospholipase C-mediated cascade: FGFR1 - Bos taurus [Pathway:R-CFA-5654219] Phospholipase C-mediated cascade: FGFR1 - Canis familiaris [Pathway:R-RNO-5654219] Phospholipase C-mediated cascade: FGFR1 - Rattus norvegicus [Pathway:R-MMU-5654219] Phospholipase C-mediated cascade: FGFR1 - Mus musculus
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5654219
summation	[Summation:191032] Phospholipase C-gamma (PLC-gamma) is a substrate of the fibr...
updateTrackers	[UpdateTracker:9782744] Update Tracker - [Pathway:5654219] Phospholipase C-mediated cascade: FGFR1 - v58:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9782744] Update Tracker - [Pathway:5654219] Phospholipase C-mediated cascade: FGFR1 - v58:[removeHasEvent]
(replacementInstances)	[Deleted:5655578] Deletion of instance: 190347
(hasEvent)	[Pathway:R-HSA-5654687] Downstream signaling of activated FGFR1