Phospholipase C-gamma (PLC-gamma) is a substrate of the fibr...

created [InstanceEdit:191033] de Bono, B, 2007-01-11 17:14:52
dbId 191032
displayName Phospholipase C-gamma (PLC-gamma) is a substrate of the fibr...
modified [InstanceEdit:1268190] Rothfels, K, 2011-05-09
schemaClass Summation
text Phospholipase C-gamma (PLC-gamma) is a substrate of the fibroblast growth factor receptor (FGFR) and other receptors with tyrosine kinase activity. It is known that the src homology region 2 (SH2 domain) of PLC-gamma and of other signaling molecules (such as GTPase-activating protein and phosphatidylinositol 3-kinase-associated p85) direct their binding toward autophosphorylated tyrosine residues of the FGFR. Recruitment of PLC-gamma results in its phosphorylation and activation by the receptor. Activated PLC-gamma hydrolyzes phosphatidyl inositol[4,5] P2 to form the second messengers diacylglycerol (DAG) and Ins [1,4,5]P3, which stimulate calcium release and activation of calcium/calmodulin dependent kinases.
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