Formation of ragulator

Stable Identifier
R-HSA-5653936
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

A complex of LAMTOR1 to 5, known as Ragulator, interacts with Rag GTPases recruiting them to lysosomes, an essential step in mTORC1 activation (Sancak et al. 2010). LAMTOR1 is probably myristoylated and/or palmitoylated to enhance its assocation with the lysosomal surface, acting as a platform for the other members of the compex. Lamtor1 (Nada et al. 2009) and Lamtor2 (Teis et al. 2006) knockout mice exhibit severe growth retardation, severe defects in intracellular organelle organization and embryonic lethality. Partial reduction of LAMTOR2 in humans leads to reduced height (Bohn et al. 2007).

Literature References
PubMed ID Title Journal Year
22980980 Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Bar-Peled, L, Schweitzer, LD, Zoncu, R, Sabatini, DM

Cell 2012
20381137 Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Sancak, Y, Bar-Peled, L, Zoncu, R, Markhard, AL, Nada, S, Sabatini, DM

Cell 2010
Participants
Participant Of
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Orthologous Events
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