Reactome | Formation of Ragulator complex

Formation of Ragulator complex

Stable Identifier

R-HSA-5653936

Type

Reaction [binding]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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A complex of LAMTOR1 to 5, known as Ragulator, interacts with Rag GTPases recruiting them to lysosomes, an essential step in mTORC1 activation (Sancak et al. 2010). LAMTOR1 is probably myristoylated and/or palmitoylated to enhance its assocation with the lysosomal surface, acting as a platform for the other members of the compex. Lamtor1 (Nada et al. 2009) and Lamtor2 (Teis et al. 2006) knockout mice exhibit severe growth retardation, severe defects in intracellular organelle organization and embryonic lethality. Partial reduction of LAMTOR2 in humans leads to reduced height (Bohn et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
20381137	Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Sancak, Y, Bar-Peled, L, Zoncu, R, Markhard, AL, Nada, S, Sabatini, DM	Cell	2010
22980980	Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 Bar-Peled, L, Schweitzer, LD, Zoncu, R, Sabatini, DM	Cell	2012