Reactome | B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac

Schema > Reaction > Entries

B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac Show undefined attributes

catalystActivity	[CatalystActivity:5653894] lactose synthase activity of B4GALT1:LALBA [Golgi membrane]
catalystActivityReference	[CatalystActivityReference:9643898] lactose synthase activity of B4GALT1:LALBA [Golgi membrane] Lactose biosynthesis
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:5653879] D'Eustachio, Peter, 2014-12-02
crossReference	[DatabaseIdentifier:12668112] RHEA:12405 [DatabaseIdentifier:9941994] RHEA:12405
dbId	5653878
displayName	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac
eventOf	[Pathway:R-HSA-5653890] Lactose synthesis - Homo sapiens
input	[SimpleEntity:R-ALL-964746] Glc [Golgi lumen] [SimpleEntity:R-ALL-735682] UDP-Gal [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5653880] Purification of lactose synthetase a protein from human milk and demonstration of its interaction with alpha-lactalbumin [LiteratureReference:5653887] Lactose biosynthesis [LiteratureReference:5653877] Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac UDP-alpha-D-galactose + D-glucose => lactose + UDP + H(+) Glc + UDP-Gal => Lac + UDP
orthologousEvent	[Reaction:R-BTA-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Bos taurus [Reaction:R-GGA-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Gallus gallus [Reaction:R-XTR-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Xenopus tropicalis [Reaction:R-DRE-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Danio rerio [Reaction:R-SSC-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Sus scrofa [Reaction:R-CFA-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Canis familiaris [Reaction:R-MMU-5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-5653871] Lac [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-5653886] B4GALT1 binds LALBA - Homo sapiens [Reaction:R-HSA-5653873] SLC2A1 tetramer transports Glc from cytosol to Golgi lumen - Homo sapiens [Reaction:R-HSA-735702] SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5668911] Jassal, Bijay, 2015-01-29 [InstanceEdit:9943299] Hill, David P, 2025-03-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5653878
summation	[Summation:5655208] In the Golgi membrane, the B4GALT1 subunit of the B4GALT1:LA...
updateTrackers	[UpdateTracker:9953653] Update Tracker - [Reaction:5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - v93:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9953653] Update Tracker - [Reaction:5653878] B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac - v93:[removeOutput]
(hasEvent)	[Pathway:R-HSA-5653890] Lactose synthesis

Cite Us!