Reactome | USP43 deISGylates ISG:K164,ISG:K168-PCNA

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USP43 deISGylates ISG:K164,ISG:K168-PCNA Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
catalystActivity	[CatalystActivity:5653785] ISG15-specific peptidase activity of USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5653783] Orlic-Milacic, Marija, 2014-12-01
dbId	5653786
displayName	USP43 deISGylates ISG:K164,ISG:K168-PCNA
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-5656169] Termination of translesion DNA synthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-5653838] POLD,POLE binds deISGylated PCNA after TLS - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-HSA-5653781] USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5653648] Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	USP43 deISGylates ISG:K164,ISG:K168-PCNA
orthologousEvent	[Reaction:R-SSC-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA - Sus scrofa [Reaction:R-BTA-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA - Bos taurus [Reaction:R-CFA-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA - Canis familiaris [Reaction:R-RNO-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA - Rattus norvegicus [Reaction:R-MMU-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA - Mus musculus
output	2 × [EntityWithAccessionedSequence:R-HSA-5653665] ISG15 [nucleoplasm] [Complex:R-HSA-5653782] PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5653784] USP43 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5653780] USP43 binds ISG:K164,ISG:K168-PCNA - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5653786
summation	[Summation:5653806] USP43 acts as an ISG15 protease to cleave ISG15 from lysines...

Referrals

(hasEvent)	[Pathway:R-HSA-5656169] Termination of translesion DNA synthesis
(precedingEvent)	[Reaction:R-HSA-5653838] POLD,POLE binds deISGylated PCNA after TLS

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