Reactome | USP43 deISGylates ISG:K164,ISG:K168-PCNA

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USP43 deISGylates ISG:K164,ISG:K168-PCNA Show undefined attributes

catalystActivity	[CatalystActivity:10180653] ISG15-specific peptidase activity of USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180655
displayName	USP43 deISGylates ISG:K164,ISG:K168-PCNA
eventOf	[Pathway:R-RNO-5656169] Termination of translesion DNA synthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5653838] POLD,POLE binds deISGylated PCNA after TLS - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-RNO-5653781] USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	USP43 deISGylates ISG:K164,ISG:K168-PCNA
output	2 × [EntityWithAccessionedSequence:R-RNO-5653665] Isg15 [nucleoplasm] [Complex:R-RNO-5653782] PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-5653784] Usp43 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5653780] USP43 binds ISG:K164,ISG:K168-PCNA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5653786
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5656169] Termination of translesion DNA synthesis
(precedingEvent)	[Reaction:R-RNO-5653838] POLD,POLE binds deISGylated PCNA after TLS
(inferredTo)	[Reaction:R-HSA-5653786] USP43 deISGylates ISG:K164,ISG:K168-PCNA

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