USP43 deISGylates ISG:K164,ISG:K168-PCNA

Stable Identifier
R-HSA-5653786
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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USP43 deISGylates ISG:K164,ISG:K168-PCNA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
USP43 acts as an ISG15 protease to cleave ISG15 from lysines K164 and K168 of PCNA, thus deISGylating PCNA (Park et al. 2014).
Literature References
PubMed ID Title Journal Year
24768535 Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis

Lee, SW, Seol, JH, Yang, SW, Yu, KR, Park, JM, Ka, SH, Jeon, YJ, Chung, CH

Mol. Cell 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ISG15-specific peptidase activity of USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]

Physical Entity
USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
Activity
ISG15-specific peptidase activity (GO:0019785)
Orthologous Events
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Bos taurus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Canis familiaris)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Mus musculus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Plasmodium falciparum)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Rattus norvegicus)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Sus scrofa)
Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-12-02)
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