Reactome | PCNA-containing replication complex binds damaged dsDNA

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PCNA-containing replication complex binds damaged dsDNA Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5651999] Orlic-Milacic, Marija, 2014-11-26
dbId	5651992
displayName	PCNA-containing replication complex binds damaged dsDNA
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-110314] Recognition of DNA damage by PCNA-containing replication complex - Homo sapiens
followingEvent	[Reaction:R-HSA-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA - Homo sapiens
input	[DefinedSet:R-HSA-5651987] Damaged DNA Template [nucleoplasm] [Complex:R-HSA-5651799] PCNA:POLD,POLE:RPA:RFC [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5651998] RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCNA-containing replication complex binds damaged dsDNA
output	[Complex:R-HSA-5651995] PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5652137] Damaged dsDNA becomes damaged DNA template - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5651992
summation	[Summation:5651990] The replication complex consisting of PCNA, DNA polymerase d...

Referrals

(hasEvent)	[Pathway:R-HSA-110314] Recognition of DNA damage by PCNA-containing replication complex
(precedingEvent)	[Reaction:R-HSA-5652005] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA

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