PCNA-containing replication complex binds damaged dsDNA

Stable Identifier
R-HSA-5651992
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PCNA-containing replication complex binds damaged dsDNA
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The replication complex consisting of PCNA, DNA polymerase delta complex (POLD) or DNA polymerase epsilon complex (POLE), RPA and RFC complexes, encounters damaged dsDNA that cannot be used as a template by replicative DNA polymerases POLD or POLE (Hoege et al. 2002).
Literature References
PubMed ID Title Journal Year
12226657 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Moldovan, GL, Hoege, C, Pfander, B, Pyrowolakis, G, Jentsch, S

Nature 2002
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as an event of
Authored
Orlic-Milacic, M  (2014-12-11)
Reviewed
Borowiec, JA  (2015-01-07)
Created
Orlic-Milacic, M  (2014-11-27)
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