PCNA-containing replication complex binds damaged dsDNA

Stable Identifier
R-HSA-5651992
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The replication complex consisting of PCNA, DNA polymerase delta complex (POLD) or DNA polymerase epsilon complex (POLE), RPA and RFC complexes, encounters damaged dsDNA that cannot be used as a template by replicative DNA polymerases POLD or POLE (Hoege et al. 2002).

Literature References
PubMed ID Title Journal Year
12226657 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Hoege, C, Pfander, B, Moldovan, GL, Pyrowolakis, G, Jentsch, S

Nature 2002
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