Reactome | PARG dePARylates PARP1,PARP2

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PARG dePARylates PARP1,PARP2 Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
catalystActivity	[CatalystActivity:5651840] poly(ADP-ribose) glycohydrolase activity of PARG [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5651831] Orlic-Milacic, Marija, 2014-11-25
dbId	5651828
displayName	PARG dePARylates PARP1,PARP2
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-HSA-5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5651830] NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1 [LiteratureReference:5651836] Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase [LiteratureReference:5651874] PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PARG dePARylates PARP1,PARP2
orthologousEvent	[Reaction:R-DDI-5651828] PARG dePARylates PARP1,PARP2 - Dictyostelium discoideum [Reaction:R-GGA-5651828] PARG dePARylates PARP1,PARP2 - Gallus gallus [Reaction:R-XTR-5651828] PARG dePARylates PARP1,PARP2 - Xenopus tropicalis [Reaction:R-DRE-5651828] PARG dePARylates PARP1,PARP2 - Danio rerio [Reaction:R-SSC-5651828] PARG dePARylates PARP1,PARP2 - Sus scrofa [Reaction:R-BTA-5651828] PARG dePARylates PARP1,PARP2 - Bos taurus [Reaction:R-RNO-5651828] PARG dePARylates PARP1,PARP2 - Rattus norvegicus [Reaction:R-MMU-5651828] PARG dePARylates PARP1,PARP2 - Mus musculus
output	[SimpleEntity:R-ALL-5651834] ADP-D-ribose [nucleoplasm] [Complex:R-HSA-5649884] PARP1,PARP2 dimers [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5651828
summation	[Summation:5651827] PARG acts as a poly(ADP-ribosyl)glycohydrolase (PAR glycohyd...

Referrals

(hasEvent)

[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair