Reactome | PARG dePARylates PARP1,PARP2

Schema > Reaction > Entries

PARG dePARylates PARP1,PARP2 Show undefined attributes

catalystActivity	[CatalystActivity:10057708] poly(ADP-ribose) glycohydrolase activity of PARG [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10057710
displayName	PARG dePARylates PARP1,PARP2
eventOf	[Pathway:R-MMU-110362] POLB-Dependent Long Patch Base Excision Repair - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5651828] PARG dePARylates PARP1,PARP2 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-MMU-5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PARG dePARylates PARP1,PARP2
output	[SimpleEntity:R-ALL-5651834] ADP-D-ribose [nucleoplasm] [Complex:R-MMU-5649884] PARP1,PARP2 dimers [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5651828
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-110362] POLB-Dependent Long Patch Base Excision Repair
(inferredTo)	[Reaction:R-HSA-5651828] PARG dePARylates PARP1,PARP2

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