LIG1 bound to POLB ligates SSB

Stable Identifier
Reaction [transition]
Homo sapiens
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LIG1 (DNA ligase I), recruited to the long-patch base excision repair site through its interaction with POLB, ligates the 3' end of the single strand break (SSB), containing the newly synthesized multiple nucleotide repair patch, with the FEN1-processed 5' end of the SSB, thus completing the base excision repair (Prigent et al. 1994, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).
Literature References
PubMed ID Title Journal Year
8264597 Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I

Prigent, C, Daly, G, Satoh, MS, Lindahl, T, Barnes, DE

Mol. Cell. Biol. 1994
11554294 Completion of base excision repair by mammalian DNA ligases

Tomkinson, AE, Motycka, TA, Mackey, ZB, Levin, DS, Leppard, JB, Chen, L, Dong, Z

Prog. Nucleic Acid Res. Mol. Biol. 2001
12200445 AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.

Ranalli, TA, Bambara, RA, Tom, S

J Biol Chem 2002
19329425 Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex

Lindsey-Boltz, LA, Sancar, A, Brandt, PD, Bambara, RA, Balakrishnan, L

J. Biol. Chem. 2009
Catalyst Activity

DNA ligase activity of LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]

Orthologous Events
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