LIG1 bound to POLB ligates SSB

Stable Identifier
R-HSA-5651789
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LIG1 (DNA ligase I), recruited to the long-patch base excision repair site through its interaction with POLB, ligates the 3' end of the single strand break (SSB), containing the newly synthesized multiple nucleotide repair patch, with the FEN1-processed 5' end of the SSB, thus completing the base excision repair (Prigent et al. 1994, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).

Literature References
PubMed ID Title Journal Year
11554294 Completion of base excision repair by mammalian DNA ligases

Tomkinson, AE, Chen, L, Dong, Z, Leppard, JB, Levin, DS, Mackey, ZB, Motycka, TA

Prog. Nucleic Acid Res. Mol. Biol. 2001
8264597 Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I

Prigent, C, Satoh, MS, Daly, G, Barnes, DE, Lindahl, T

Mol. Cell. Biol. 1994
12200445 AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.

Ranalli, TA, Tom, S, Bambara, RA

J Biol Chem 2002
19329425 Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex

Balakrishnan, L, Brandt, PD, Lindsey-Boltz, LA, Sancar, A, Bambara, RA

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA ligase activity of LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created