Reactome | NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]

Schema > Complex > Entries

NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:5649728] DNA-directed DNA polymerase activity of NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-HSA-5649723] POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution - Homo sapiens
created	[InstanceEdit:5649818] Orlic-Milacic, Marija, 2014-11-21
dbId	5649816
displayName	NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]
hasComponent	[Complex:R-HSA-110338] LIG3:XRCC1 [nucleoplasm] [CandidateSet:R-HSA-5649697] NEIL1,NEIL2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5649651] PNKP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-53845] POLB [nucleoplasm] [GenomeEncodedEntity:R-HSA-110336] SSB-gap-dsDNA [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Mus musculus [Complex:R-RNO-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Canis familiaris [Complex:R-BTA-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Bos taurus [Complex:R-SSC-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Sus scrofa [Complex:R-DRE-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Danio rerio [Complex:R-XTR-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Xenopus tropicalis [Complex:R-DDI-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Dictyostelium discoideum
isChimeric	false
literatureReference	[LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells [LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells [LiteratureReference:5649812] XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
maxDepth	3
name	NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA
producedByEvent	[Reaction:R-HSA-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5649816

Referrals

(output)	[Reaction:R-HSA-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)
(input)	[Reaction:R-HSA-5649723] POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution
(physicalEntity)	[CatalystActivity:5649728] DNA-directed DNA polymerase activity of NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]

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