Reactome | NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:11025069] DNA-directed DNA polymerase activity of NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-DDI-5649723] POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution - Dictyostelium discoideum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11025063
displayName	NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]
hasComponent	[GenomeEncodedEntity:R-DDI-5649697] Ghost homologue of NEIL1,NEIL2 [nucleoplasm] [GenomeEncodedEntity:R-DDI-110336] Ghost homologue of SSB-gap-dsDNA [nucleoplasm] [Complex:R-DDI-110338] LIG3:XRCC1 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-5649651] PNKP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-53845] polB [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] - Homo sapiens
maxDepth	3
name	NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA
producedByEvent	[Reaction:R-DDI-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) - Dictyostelium discoideum
schemaClass	Complex
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5649816
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DDI-5649723] POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution
(physicalEntity)	[CatalystActivity:11025069] DNA-directed DNA polymerase activity of NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]
(output)	[Reaction:R-DDI-5649705] PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)
(inferredTo)	[Complex:R-HSA-5649816] NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm]