Reactome | NEIL2 recognizes and binds 5-OHU-dsDNA

Schema > Reaction > Entries

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649680] Orlic-Milacic, Marija, 2014-11-20
dbId	5649686
displayName	NEIL2 recognizes and binds 5-OHU-dsDNA
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110328] Recognition and association of DNA glycosylase with site containing an affected pyrimidine - Homo sapiens
followingEvent	[Reaction:R-HSA-5649681] NEIL2 cleaves 5-OHU from damaged DNA - Homo sapiens
input	[GenomeEncodedEntity:R-HSA-110153] 5-OHU-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5649650] NEIL2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5649684] Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEIL2 recognizes and binds 5-OHU-dsDNA
output	[Complex:R-HSA-5649682] NEIL2:5-OHU-dsDNA [nucleoplasm]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5649686
summation	[Summation:5649683] NEIL2 (endonuclease 8-like protein 2), an enzyme with a dual...

(hasEvent)	[Pathway:R-HSA-110328] Recognition and association of DNA glycosylase with site containing an affected pyrimidine
(precedingEvent)	[Reaction:R-HSA-5649681] NEIL2 cleaves 5-OHU from damaged DNA

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