Reactome | phosphorylated GLI proteins bind SPOP:CUL3:RBX1

Schema > Reaction > Entries

phosphorylated GLI proteins bind SPOP:CUL3:RBX1 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10057403
displayName	phosphorylated GLI proteins bind SPOP:CUL3:RBX1
eventOf	[Pathway:R-MMU-5632684] Hedgehog 'on' state - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3 - Mus musculus
inferredFrom	[Reaction:R-HSA-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1 - Homo sapiens
input	[DefinedSet:R-MMU-5635080] 2p-GLI2,3 [nucleoplasm] [Complex:R-MMU-5635071] SPOP:CUL3:RBX1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	phosphorylated GLI proteins bind SPOP:CUL3:RBX1
output	[Complex:R-MMU-5635087] 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm]
regulatedBy	[PositiveRegulation:10057404] Positive regulation by 'DZIP1 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5635855
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5632684] Hedgehog 'on' state
(precedingEvent)	[Reaction:R-MMU-5635856] SPOP:CUL3:RBX1 ubiquitinates GLI2,3
(inferredTo)	[Reaction:R-HSA-5635855] phosphorylated GLI proteins bind SPOP:CUL3:RBX1

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