GLI proteins bind PTCH1 gene

Stable Identifier
Reaction [binding]
Homo sapiens
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PTCH1 has been identified as a Hh-responsive target in a number of genome-wide ChIP-based screens and each of the GLI proteins enhances transcription through a consensus GLI-binding site in a ligand-dependent manner (Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010; Agren et al, 2004). Expression of PTCH1 in response to Hh stimulation establishes a negative feedback loop that limits the duration of pathway activation (reviewed in Hui and Angers, 2011).

Literature References
PubMed ID Title Journal Year
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Vokes, SA, Ji, H, McCuine, S, Tenzen, T, Giles, S, Zhong, S, Longabaugh, WJ, Davidson, EH, Wong, WH, McMahon, AP

Development 2007
21801010 Gli proteins in development and disease

Hui, CC, Angers, S

Annu. Rev. Cell Dev. Biol. 2011
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Vokes, SA, Ji, H, Wong, WH, McMahon, AP

Genes Dev. 2008
15087129 Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site

Agren, M, Kogerman, P, Kleman, MI, Wessling, M, Toftgård, R

Gene 2004
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Lee, EY, Ji, H, Ouyang, Z, Zhou, B, Ma, W, Vokes, SA, McMahon, AP, Wong, WH, Scott, MP

Proc. Natl. Acad. Sci. U.S.A. 2010
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