Reactome | EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)

EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)

Stable Identifier

R-HSA-5634729

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

EHMT1:EHMT2 (KMT1D:KMT1C) methylates MeK10-histone H3 (H3K9), EHMT1:EHMT2 methylates MeK10-histone H3

ReviewStatus

5/5

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EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)

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EHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromatic histone H3 lysine-10 (H3K9) mono and di-methyltransferases in mammals (Tachibana et al. 2002, Rice et al. 2003, Tachibana et al. 2005). In vivo they exist predominantly as a heteromeric complex together with WIZ, a multi-zinc finger protein, (Ueda et al. 2006) and are responsible for global H3K9 mono- and di-methylation (Shinkai & Tchibana 2011).

Literature References

PubMed ID	Title	Journal	Year
14690610	Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains Rice, JC, Briggs, SD, Ueberheide, B, Barber, CM, Shabanowitz, J, Hunt, DF, Shinkai, Y, Allis, CD	Mol Cell	2003
12130538	G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis Tachibana, M, Sugimoto, K, Nozaki, M, Ueda, J, Ohta, T, Ohki, M, Fukuda, M, Takeda, N, Niida, H, Kato, H, Shinkai, Y	Genes Dev.	2002