Reactome | TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]

Schema > Complex > Entries

TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5634186] Shamovsky, V, 2014-11-03
dbId	5634184
displayName	TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-168651] RIPK1 [cytosol] [DefinedSet:R-HSA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-HSA-66376] TRADD [cytosol] [EntityWithAccessionedSequence:R-HSA-5634163] TRAF1 [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-66370] TRAF2 [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Mus musculus [Complex:R-RNO-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Canis familiaris [Complex:R-BTA-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Bos taurus [Complex:R-SSC-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Sus scrofa [Complex:R-DRE-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Danio rerio [Complex:R-XTR-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:5634189] TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways [LiteratureReference:5634185] TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex [LiteratureReference:5357891] Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation
maxDepth	5
memberOf	[DefinedSet:R-HSA-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane] - Homo sapiens
modified	[InstanceEdit:5661499] Shamovsky, V, 2015-01-12
name	TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1
producedByEvent	[Reaction:R-HSA-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5634184
updateTrackers	[UpdateTracker:9904389] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v82:[updateContainedComponent] [UpdateTracker:9903018] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9928631] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v91:[updateContainedComponent] [UpdateTracker:9894573] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v57:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9904389] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v82:[updateContainedComponent] [UpdateTracker:9903018] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v80:[updateContainedComponent] [UpdateTracker:9928631] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v91:[updateContainedComponent] [UpdateTracker:9894573] Update Tracker - [Complex:5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - v57:[updateContainedComponent]
(output)	[Reaction:R-HSA-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex
(hasMember)	[DefinedSet:R-HSA-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane]

© 2026 Reactome

Cite Us!