Reactome | TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10402378
displayName	TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-BTA-168651] RIPK1 [cytosol] [DefinedSet:R-BTA-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-BTA-66376] TRADD [cytosol] [EntityWithAccessionedSequence:R-BTA-5634163] TRAF1 [cytosol] 2 × [EntityWithAccessionedSequence:R-BTA-66370] TRAF2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] - Homo sapiens
maxDepth	5
memberOf	[DefinedSet:R-BTA-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane] - Bos taurus
name	TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1
producedByEvent	[Reaction:R-BTA-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5634184
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-BTA-5634221] TRAF1 binds TRAF2 within TNFR1 signaling complex
(hasMember)	[DefinedSet:R-BTA-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane]
(inferredTo)	[Complex:R-HSA-5634184] TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane]

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