Hh-Npp binds BOC:PTCH1

Stable Identifier
Reaction [binding]
Homo sapiens
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Hh pathway activation depends upon the binding of Hh ligand to the PTCH transmembrane receptor (Chen and Struhl, 1996; Marigo et al, 1996; Stone et al, 1996). Ligand binding relieves the PTCH-dependent inhibition of SMO, allowing SMO to concentrate in the primary cilium and promoting the accumulation of the full-length form of the GLI transcriptional proteins (reviewed in Briscoe and Therond, 2013). PTCH also binds constitutively to the transmembrane protein BOC (brother of CDO), one of three vertebrate co-receptors required for Hh signaling in mice (Izzi et al, 2011; Allen et al, 2011; reviewed in Sanchez-Arrones et al, 2012). BOC interacts with PTCH through the first and second of the BOC fibronectin type 3 (FNIII) repeats, and with SHH through the third FNIII repeat, suggesting the formation of a ternary complex in the presence of ligand (Okada et al, 2006; Izzi et al, 2011). Although GAS1 similarly binds to both PTCH and Hh, it is not co-immunoprecipitated with BOC, suggesting the formation of separate receptor:co-receptor complexes (Izzi et al, 2011; Allen et al, 2011; reviewed in Briscoe and Therond, 2013).

Literature References
PubMed ID Title Journal Year
8906787 The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Stone, DM, de Sauvage, F, Hooper, JE, Gu, Q, Pennica, D, Goddard, A, Rosenthal, A, Phillips, H, Noll, M, Swanson, TA, Johnson, RL, Armanini, M, Hynes, M, Scott, MP

Nature 1996
8898207 Dual roles for patched in sequestering and transducing Hedgehog

Chen, Y, Struhl, G

Cell 1996
8906794 Biochemical evidence that patched is the Hedgehog receptor

Davey, RA, Cunningham, JM, Marigo, V, Zuo, Y, Tabin, CJ

Nature 1996
21664577 Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

Charron, F, Morin, S, Krauss, RS, Allen, BL, Laniel, D, Lévesque, M, McMahon, AP, Mille, F, Wilkes, BC, Izzi, L

Dev. Cell 2011
17086203 Boc is a receptor for sonic hedgehog in the guidance of commissural axons

Charron, F, Fabre, PJ, Morin, S, Okada, A, Wong, K, McConnell, SK, Tessier-Lavigne, M, Shin, DS

Nature 2006
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Thérond, PP, Briscoe, J

Nat. Rev. Mol. Cell Biol. 2013
22326621 Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication

Nieto-Lopez, F, Cardozo, M, Bovolenta, P, Sanchez-Arrones, L

Int. J. Biochem. Cell Biol. 2012
21664576 Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function

Charron, F, Song, JY, Krauss, RS, Allen, BL, McMahon, AP, Althaus, IW, Kang, JS, Izzi, L

Dev. Cell 2011
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