Reactome | Hh-Npp binds CDON and PTCH

Hh-Npp binds CDON and PTCH

Stable Identifier

R-HSA-5632652

Type

Reaction [binding]

Species

Homo sapiens

Compartment

ciliary membrane

ReviewStatus

5/5

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CDON is a transmembrane glycoprotein that binds directly to Hh ligand and is required in conjunction with PTCH, BOC and GAS1 to promote Hh signaling (Tenzen et al, 2006; McLellan et al, 2008; Kavran et al, 2010; Bae et al, 2011; reviewed in Beachy et al, 2010; Sanchez-Arrones et al, 2012). Conserved fibronectin type III repeats in the extracellular region of CDON and BOC are required for interaction with both Hh ligand and the PTCH receptor and also for interactions between BOC, CDON and GAS1 (Okada et al, 2006; Izzi et al, 2011; Bae et al, 2011). The manner in which each of these co-receptors interact and contribute to Hh signaling is not fully elucidated, but knockout of all three is required to abrogate Hh signaling in mice (Allen et al, 2007; Allen et al, 2011; Izzi et al, 2011; reviewed in Sanchez-Arrones et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
20519495	All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner Kavran, JM, Oladosu, OO, Leahy, DJ, Mulepati, S, Ward, MD	J. Biol. Chem.	2010
17504941	The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development Allen, BL, McMahon, AP, Tenzen, T	Genes Dev.	2007
21664577	Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation Charron, F, Morin, S, Krauss, RS, Allen, BL, Laniel, D, Lévesque, M, McMahon, AP, Mille, F, Wilkes, BC, Izzi, L	Dev. Cell	2011
16647304	The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice Krauss, RS, Allen, BL, McMahon, AP, Cole, F, Tenzen, T, Kang, JS	Dev. Cell	2006
17086203	Boc is a receptor for sonic hedgehog in the guidance of commissural axons Charron, F, Fabre, PJ, Morin, S, Okada, A, Wong, K, McConnell, SK, Tessier-Lavigne, M, Shin, DS	Nature	2006
20844013	Interactions between Hedgehog proteins and their binding partners come into view Hymowitz, SG, Beachy, PA, Leahy, DJ, Lazarus, RA, Siebold, C	Genes Dev.	2010
21664576	Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function Charron, F, Song, JY, Krauss, RS, Allen, BL, McMahon, AP, Althaus, IW, Kang, JS, Izzi, L	Dev. Cell	2011
22326621	Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication Nieto-Lopez, F, Cardozo, M, Bovolenta, P, Sanchez-Arrones, L	Int. J. Biochem. Cell Biol.	2012
21802063	Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors Muenke, M, Roessler, E, Krauss, RS, Schachter, K, Domené, S, Bae, GU, Kang, JS	Am. J. Hum. Genet.	2011
18794898	The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla Ghirlando, R, Beachy, PA, Zheng, X, Leahy, DJ, Hauk, G, McLellan, JS	Nature	2008