Hh-Npp binds CDON and PTCH

Stable Identifier
Reaction [binding]
Homo sapiens
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CDON is a transmembrane glycoprotein that binds directly to Hh ligand and is required in conjunction with PTCH, BOC and GAS1 to promote Hh signaling (Tenzen et al, 2006; McLellan et al, 2008; Kavran et al, 2010; Bae et al, 2011; reviewed in Beachy et al, 2010; Sanchez-Arrones et al, 2012). Conserved fibronectin type III repeats in the extracellular region of CDON and BOC are required for interaction with both Hh ligand and the PTCH receptor and also for interactions between BOC, CDON and GAS1 (Okada et al, 2006; Izzi et al, 2011; Bae et al, 2011). The manner in which each of these co-receptors interact and contribute to Hh signaling is not fully elucidated, but knockout of all three is required to abrogate Hh signaling in mice (Allen et al, 2007; Allen et al, 2011; Izzi et al, 2011; reviewed in Sanchez-Arrones et al, 2012).

Literature References
PubMed ID Title Journal Year
20519495 All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner

Kavran, JM, Oladosu, OO, Leahy, DJ, Mulepati, S, Ward, MD

J. Biol. Chem. 2010
17504941 The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

Allen, BL, McMahon, AP, Tenzen, T

Genes Dev. 2007
21664577 Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation

Charron, F, Morin, S, Krauss, RS, Allen, BL, Laniel, D, Lévesque, M, McMahon, AP, Mille, F, Wilkes, BC, Izzi, L

Dev. Cell 2011
16647304 The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

Krauss, RS, Allen, BL, McMahon, AP, Cole, F, Tenzen, T, Kang, JS

Dev. Cell 2006
17086203 Boc is a receptor for sonic hedgehog in the guidance of commissural axons

Charron, F, Fabre, PJ, Morin, S, Okada, A, Wong, K, McConnell, SK, Tessier-Lavigne, M, Shin, DS

Nature 2006
20844013 Interactions between Hedgehog proteins and their binding partners come into view

Hymowitz, SG, Beachy, PA, Leahy, DJ, Lazarus, RA, Siebold, C

Genes Dev. 2010
21664576 Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function

Charron, F, Song, JY, Krauss, RS, Allen, BL, McMahon, AP, Althaus, IW, Kang, JS, Izzi, L

Dev. Cell 2011
22326621 Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication

Nieto-Lopez, F, Cardozo, M, Bovolenta, P, Sanchez-Arrones, L

Int. J. Biochem. Cell Biol. 2012
21802063 Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors

Muenke, M, Roessler, E, Krauss, RS, Schachter, K, Domené, S, Bae, GU, Kang, JS

Am. J. Hum. Genet. 2011
18794898 The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

Ghirlando, R, Beachy, PA, Zheng, X, Leahy, DJ, Hauk, G, McLellan, JS

Nature 2008
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