TIGAR was first identified as a TP53 target through high-throughput gene expression profiling (Jen and Cheung 2005). TP53 stimulates TIGAR transcription, although TIGAR can be regulated through TP53-independent mechanisms, including TP53 family members TP63 (p63) and TP73 (p73). TIGAR is induced by TP53 under low stress levels and decreases under high stress levels (Bensaad et al. 2006). TIGAR functions as a fructose-2,6-bisphosphatase, thereby lowering glycolytic flux and promoting antioxidant functions. By protecting cells from oxidative stress, TIGAR may mediate some of the tumor suppressor activity of p53 but could also contribute to tumorigenesis. (Bensaad, 2006, Lee et al. 2014).
Bensaad, K, Tsuruta, A, Selak, MA, Vidal, MN, Nakano, K, Bartrons, R, Gottlieb, E, Vousden, KH
Venkatanarayan, A, Raulji, P, Norton, W, Flores, ER
Jen, KY, Cheung, VG
Lee, P, Vousden, KH, Cheung, EC
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