Reactome | TNFR1-mediated ceramide production

Schema > Pathway > Entries

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445542
displayName	TNFR1-mediated ceramide production
eventOf	[Pathway:R-BTA-75893] TNF signaling - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221467] positive regulation of ceramide biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-5626988] TNF-?:TNFR1 binds NSMAF - Bos taurus [Reaction:R-BTA-5626982] TNF-?:TNFR1:NSMAF binds RACK1 - Bos taurus [Reaction:R-BTA-5626981] TNF-?:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 - Bos taurus
inferredFrom	[Pathway:R-HSA-5626978] TNFR1-mediated ceramide production - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TNFR1-mediated ceramide production
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-5626978
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-75893] TNF signaling
(inferredTo)	[Pathway:R-HSA-5626978] TNFR1-mediated ceramide production

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