Reactome | GTP-bound RAC1 and CDC42 bind IQGAPs

GTP-bound RAC1 and CDC42 bind IQGAPs

Stable Identifier

R-HSA-5626469

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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IQGAP proteins IQGAP1, IQGAP2 and IQGAP3, bind Rho GTPases RAC1 and CDC42 via the RAS GTPase-activating protein-related domain (GRD) of IQGAPs. Although the GRDs are homologous to the RAS-specific GAP (GTPase activating protein) domains, they do not possess GAP activity. Instead, they increase the amount of activated CDC42 and RAC1 in the cell by stabilizing them in the GTP-bound state (Kuroda et al. 1996, Swart-Mataraza et al. 2002, Wang et al. 2007, Pelikan-Conchaudron et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
11948177	IQGAP1 is a component of Cdc42 signaling to the cytoskeleton Swart-Mataraza, JM, Li, Z, Sacks, DB	J. Biol. Chem.	2002
17244649	IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth Wang, S, Watanabe, T, Noritake, J, Fukata, M, Yoshimura, T, Itoh, N, Harada, T, Nakagawa, M, Matsuura, Y, Arimura, N, Kaibuchi, K	J. Cell. Sci.	2007
8798539	Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1 Kuroda, S, Fukata, M, Kobayashi, K, Nakafuku, M, Nomura, N, Iwamatsu, A, Kaibuchi, K	J. Biol. Chem.	1996
9199170	IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments Bashour, AM, Fullerton, AT, Hart, MJ, Bloom, GS	J. Cell Biol.	1997
21730051	The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration Pelikan-Conchaudron, A, Le Clainche, C, Didry, D, Carlier, MF	J. Biol. Chem.	2011