Reactome | SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+

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SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ Show undefined attributes

authored	[InstanceEdit:5626309] Jassal, Bijay, 2014-10-09
catalystActivity	[CatalystActivity:5626310] calcium, potassium:sodium antiporter activity of SLC24A5 [trans-Golgi network membrane]
category	transition
compartment	[Compartment:263163] trans-Golgi network membrane [Compartment:70101] cytosol [Compartment:17963] Golgi lumen
created	[InstanceEdit:5626309] Jassal, Bijay, 2014-10-09
crossReference	[DatabaseIdentifier:12668190] RHEA:69967 [DatabaseIdentifier:9958467] RHEA:69969
dbId	5626316
diseaseReaction	[FailedReaction:R-HSA-5626356] Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Homo sapiens
displayName	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+
edited	[InstanceEdit:5626309] Jassal, Bijay, 2014-10-09
eventOf	[Pathway:R-HSA-425561] Sodium/Calcium exchangers - Homo sapiens
input	[SimpleEntity:R-ALL-167012] Ca2+ [Golgi lumen] [SimpleEntity:R-ALL-5626313] K+ [Golgi lumen] 4 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5626305] SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+
orthologousEvent	[Reaction:R-DME-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Drosophila melanogaster [Reaction:R-GGA-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Gallus gallus [Reaction:R-XTR-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Xenopus tropicalis [Reaction:R-SSC-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Sus scrofa [Reaction:R-BTA-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Bos taurus [Reaction:R-CFA-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Canis familiaris [Reaction:R-RNO-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Rattus norvegicus [Reaction:R-MMU-5626316] SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ - Mus musculus
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [SimpleEntity:R-ALL-29804] K+ [cytosol] 4 × [SimpleEntity:R-ALL-425958] Na+ [Golgi lumen]
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
revised	[InstanceEdit:5626309] Jassal, Bijay, 2014-10-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5626316
summation	[Summation:5626307] The five members of the NCKX (SLC24) family are all able to ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5626356] Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+
(hasEvent)	[Pathway:R-HSA-425561] Sodium/Calcium exchangers