SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+

Stable Identifier
R-HSA-5626316
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. SLC24A5 encodes a trans-Golgi network exchanger protein NCKX5 which is expressed in melanocytes and regulates human epidermal melanogenesis (Ginger et al. 2008).

Literature References
PubMed ID Title Journal Year
18166528 SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis

Ginger, RS, Askew, SE, Ogborne, RM, Wilson, S, Ferdinando, D, Dadd, T, Smith, AM, Kazi, S, Szerencsei, RT, Winkfein, RJ, Schnetkamp, PP, Green, MR

J. Biol. Chem. 2008
Participants
Participates
Catalyst Activity

calcium, potassium:sodium antiporter activity of SLC24A5 [trans-Golgi network membrane]

Orthologous Events
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