SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+

Stable Identifier
R-HSA-5626316
Type
Reaction [transition]
Species
Homo sapiens
Compartment
trans-Golgi network membrane, cytosol, Golgi lumen
ReviewStatus
5/5
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SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+
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The five members of the NCKX (SLC24) family are all able to exchange one Ca2+ and one K+ for four Na+. SLC24A5 encodes a trans-Golgi network exchanger protein NCKX5 which is expressed in melanocytes and regulates human epidermal melanogenesis (Ginger et al. 2008).
Literature References
PubMed ID Title Journal Year
18166528 SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis

Ginger, RS, Askew, SE, Ogborne, RM, Wilson, S, Ferdinando, D, Dadd, T, Smith, AM, Kazi, S, Szerencsei, RT, Winkfein, RJ, Schnetkamp, PP, Green, MR

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calcium, potassium:sodium antiporter activity of SLC24A5 [trans-Golgi network membrane]

Physical Entity
SLC24A5 [trans-Golgi network membrane] (Homo sapiens)
Activity
calcium, potassium:sodium antiporter activity (GO:0008273)
Orthologous Events
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Bos taurus)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Canis familiaris)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Drosophila melanogaster)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Gallus gallus)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Mus musculus)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Rattus norvegicus)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Sus scrofa)
SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+ (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2014-10-09)
Reviewed
He, L  (2009-08-24)
Created
Jassal, B  (2014-10-09)
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