Reactome | RAF1 binds p21 RAS:GTP

Schema > Reaction > Entries

RAF1 binds p21 RAS:GTP Show undefined attributes

authored	[InstanceEdit:5660664] Garapati, P V, 2015-01-04
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5624475] Garapati, P V, 2014-09-29
dbId	5624494
displayName	RAF1 binds p21 RAS:GTP
edited	[InstanceEdit:5660664] Garapati, P V, 2015-01-04
eventOf	[Pathway:R-HSA-5621575] CD209 (DC-SIGN) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5624492] PAK phosphorylates p21 RAF1 on S338 - Homo sapiens
input	[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167205] RAF1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5607189] C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB [LiteratureReference:443446] Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner [LiteratureReference:1497944] The RAF proteins take centre stage
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	RAF1 binds p21 RAS:GTP
orthologousEvent	[Reaction:R-RNO-5624494] RAF1 binds p21 RAS:GTP - Rattus norvegicus [Reaction:R-DDI-5624494] RAF1 binds p21 RAS:GTP - Dictyostelium discoideum [Reaction:R-CEL-5624494] RAF1 binds p21 RAS:GTP - Caenorhabditis elegans [Reaction:R-DME-5624494] RAF1 binds p21 RAS:GTP - Drosophila melanogaster [Reaction:R-GGA-5624494] RAF1 binds p21 RAS:GTP - Gallus gallus [Reaction:R-XTR-5624494] RAF1 binds p21 RAS:GTP - Xenopus tropicalis [Reaction:R-DRE-5624494] RAF1 binds p21 RAS:GTP - Danio rerio [Reaction:R-CFA-5624494] RAF1 binds p21 RAS:GTP - Canis familiaris [Reaction:R-MMU-5624494] RAF1 binds p21 RAS:GTP - Mus musculus
output	[Complex:R-HSA-5624478] p21 RAS:GTP:RAF1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5621573] CD209 activate GTPase RAS - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5624494
summation	[Summation:5624479] Upon CLEC7A (Dectin-1) and CD209 (DC-SIGN) activation, RAF1 ...

Referrals

(hasEvent)	[Pathway:R-HSA-5621575] CD209 (DC-SIGN) signaling
(precedingEvent)	[Reaction:R-HSA-5624492] PAK phosphorylates p21 RAF1 on S338