Reactome | RAF1 binds p21 RAS:GTP

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10613745
displayName	RAF1 binds p21 RAS:GTP
eventOf	[Pathway:R-DRE-5621575] CD209 (DC-SIGN) signaling - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-5624492] PAK phosphorylates p21 RAF1 on S338 - Danio rerio
inferredFrom	[Reaction:R-HSA-5624494] RAF1 binds p21 RAS:GTP - Homo sapiens
input	[Complex:R-DRE-109783] p21 RAS:GTP [plasma membrane] [EntityWithAccessionedSequence:R-DRE-167205] RAF1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAF1 binds p21 RAS:GTP
output	[Complex:R-DRE-5624478] p21 RAS:GTP:RAF1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-5624494
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-5621575] CD209 (DC-SIGN) signaling
(precedingEvent)	[Reaction:R-DRE-5624492] PAK phosphorylates p21 RAF1 on S338
(inferredTo)	[Reaction:R-HSA-5624494] RAF1 binds p21 RAS:GTP

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