Reactome | RAF1 binds p21 RAS:GTP

RAF1 binds p21 RAS:GTP

Stable Identifier

R-HSA-5624494

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Upon CLEC7A (Dectin-1) and CD209 (DC-SIGN) activation, RAF1 translocates to the membrane through interaction with the active form of RAS. This interaction induces a conformational change in RAF1 and is required for RAF1 activation (Gringhuis et al. 2007, Wellbrock et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
7517401	Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner Cleghon, V, Morrison, DK	J Biol Chem	1994
15520807	The RAF proteins take centre stage Wellbrock, C, Karasarides, M, Marais, R	Nat Rev Mol Cell Biol	2004
17462920	C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB Gringhuis, SI, den Dunnen, J, Litjens, M, van Het Hof, B, van Kooyk, Y, Geijtenbeek, TB	Immunity	2007