Reactome | RAF1 binds p21 RAS:GTP

RAF1 binds p21 RAS:GTP

Stable Identifier

R-HSA-5624494

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Upon CLEC7A (Dectin-1) and CD209 (DC-SIGN) activation, RAF1 translocates to the membrane through interaction with the active form of RAS. This interaction induces a conformational change in RAF1 and is required for RAF1 activation (Gringhuis et al. 2007, Wellbrock et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15520807	The RAF proteins take centre stage Wellbrock, C, Karasarides, M, Marais, R	Nat Rev Mol Cell Biol	2004
7517401	Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner Cleghon, V, Morrison, DK	J Biol Chem	1994
17462920	C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB Gringhuis, SI, den Dunnen, J, Litjens, M, van Het Hof, B, van Kooyk, Y, Geijtenbeek, TB	Immunity	2007