Reactome | Trafficking of myristoylated proteins to the cilium

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Trafficking of myristoylated proteins to the cilium Show undefined attributes

authored	[InstanceEdit:5623547] Rothfels, Karen, 2014-09-15
created	[InstanceEdit:5624137] Rothfels, Karen, 2014-09-19
dbId	5624138
displayName	Trafficking of myristoylated proteins to the cilium
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620920] Cargo trafficking to the periciliary membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:376831] cilium assembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5624131] UNC119B binds myristoylated proteins - Homo sapiens [BlackBoxEvent:R-HSA-5624132] UNC119B stimulates translocation of myristoylated ciliary cargo to the primary cilium - Homo sapiens [Reaction:R-HSA-5624133] ARL3:GTP binds the UNC119B complex - Homo sapiens [Reaction:R-HSA-5624130] Myristoylated NPHP3 translocates into the ciliary membrane - Homo sapiens [Reaction:R-HSA-5638004] RP2 binds ARL3:GTP:UNC119B - Homo sapiens [Reaction:R-HSA-5638007] RP2 activates the GTPase activity of ARL3 - Homo sapiens [Reaction:R-HSA-5638006] ARL3 hydrolyzes GTP - Homo sapiens [Reaction:R-HSA-5638016] RP2:ARL3:GDP:UNC119B dissociates - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:5623984] An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium [LiteratureReference:5623989] Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins [LiteratureReference:5624017] The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis [LiteratureReference:5623331] The emerging role of Arf/Arl small GTPases in cilia and ciliopathies
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Trafficking of myristoylated proteins to the cilium
orthologousEvent	[Pathway:R-CEL-5624138] Trafficking of myristoylated proteins to the cilium - Caenorhabditis elegans [Pathway:R-GGA-5624138] Trafficking of myristoylated proteins to the cilium - Gallus gallus [Pathway:R-DRE-5624138] Trafficking of myristoylated proteins to the cilium - Danio rerio [Pathway:R-BTA-5624138] Trafficking of myristoylated proteins to the cilium - Bos taurus [Pathway:R-CFA-5624138] Trafficking of myristoylated proteins to the cilium - Canis familiaris [Pathway:R-RNO-5624138] Trafficking of myristoylated proteins to the cilium - Rattus norvegicus [Pathway:R-MMU-5624138] Trafficking of myristoylated proteins to the cilium - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5624138
summation	[Summation:5624025] A number of myristoylated proteins have been shown to traffi...
updateTrackers	[UpdateTracker:9782410] Update Tracker - [Pathway:5624138] Trafficking of myristoylated proteins to the cilium - v59:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782410] Update Tracker - [Pathway:5624138] Trafficking of myristoylated proteins to the cilium - v59:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5620920] Cargo trafficking to the periciliary membrane