Reactome | RP2 binds ARL3:GTP:UNC119B

Schema > Reaction > Entries

RP2 binds ARL3:GTP:UNC119B Show undefined attributes

authored	[InstanceEdit:5638001] Rothfels, Karen, 2014-10-30
category	binding
compartment	[Compartment:18730] cilium
created	[InstanceEdit:5638008] Rothfels, Karen, 2014-11-13
dbId	5638004
displayName	RP2 binds ARL3:GTP:UNC119B
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5624138] Trafficking of myristoylated proteins to the cilium - Homo sapiens
followingEvent	[Reaction:R-HSA-5638007] RP2 activates the GTPase activity of ARL3 - Homo sapiens
input	[Complex:R-HSA-5624076] ARL3:GTP:UNC119B [cilium] [EntityWithAccessionedSequence:R-HSA-5624052] RP2 [cilium]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5624006] Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex [LiteratureReference:5624002] Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2 [LiteratureReference:5624015] The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium [LiteratureReference:5623984] An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium [LiteratureReference:5624013] The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 [LiteratureReference:5623996] Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3 [LiteratureReference:5623331] The emerging role of Arf/Arl small GTPases in cilia and ciliopathies [LiteratureReference:5623989] Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RP2 binds ARL3:GTP:UNC119B
orthologousEvent	[Reaction:R-CEL-5638004] RP2 binds ARL3:GTP:UNC119B - Caenorhabditis elegans [Reaction:R-GGA-5638004] RP2 binds ARL3:GTP:UNC119B - Gallus gallus [Reaction:R-DRE-5638004] RP2 binds ARL3:GTP:UNC119B - Danio rerio [Reaction:R-BTA-5638004] RP2 binds ARL3:GTP:UNC119B - Bos taurus [Reaction:R-CFA-5638004] RP2 binds ARL3:GTP:UNC119B - Canis familiaris [Reaction:R-RNO-5638004] RP2 binds ARL3:GTP:UNC119B - Rattus norvegicus [Reaction:R-MMU-5638004] RP2 binds ARL3:GTP:UNC119B - Mus musculus
output	[Complex:R-HSA-5637985] RP2:ARL3:GTP:UNC119B [cilium]
precedingEvent	[Reaction:R-HSA-5624130] Myristoylated NPHP3 translocates into the ciliary membrane - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5638004
summation	[Summation:5624039] RP2 is an ARL3 GAP that is localized to the cilium and plays...
updateTrackers	[UpdateTracker:9782196] Update Tracker - [Reaction:5638004] RP2 binds ARL3:GTP:UNC119B - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782196] Update Tracker - [Reaction:5638004] RP2 binds ARL3:GTP:UNC119B - v59:[modifyText]
(hasEvent)	[Pathway:R-HSA-5624138] Trafficking of myristoylated proteins to the cilium
(precedingEvent)	[Reaction:R-HSA-5638007] RP2 activates the GTPase activity of ARL3

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