Reactome | ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex

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ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex Show undefined attributes

authored	[InstanceEdit:5620934] Rothfels, Karen, 2014-08-27
category	binding
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:5620915] Rothfels, Karen, 2014-08-27
dbId	5620921
displayName	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620916] VxPx cargo-targeting to cilium - Homo sapiens
followingEvent	[Reaction:R-HSA-5623513] ASAP1 stimulates GTPase activity of ARF4 - Homo sapiens
input	[Complex:R-HSA-5623429] ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] [Complex:R-HSA-5623431] RAB11A:GTP [cytosol] [Complex:R-HSA-5623435] RAB11FIP3 dimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5623289] Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome [LiteratureReference:5623294] Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 [LiteratureReference:5623329] The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting [LiteratureReference:5623322] Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1 [LiteratureReference:5623323] Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes [LiteratureReference:5623306] Molecular characterization of Rab11-FIP3 binding to ARF GTPases [LiteratureReference:5623300] Crosstalk of Arf and Rab GTPases en route to cilia
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex
orthologousEvent	[Reaction:R-DME-5620921] ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex - Drosophila melanogaster [Reaction:R-GGA-5620921] ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex - Gallus gallus [Reaction:R-SSC-5620921] ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex - Sus scrofa [Reaction:R-BTA-5620921] ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex - Bos taurus [Reaction:R-CFA-5620921] ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex - Canis familiaris [Reaction:R-MMU-5620921] ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex - Mus musculus
output	[Complex:R-HSA-5623434] RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane]
precedingEvent	[Reaction:R-HSA-5620918] ASAP1 dimer binds membrane proteins - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5620921
summation	[Summation:5623357] Recruitment of ASAP1 to the TGN facilitates the subsequent r...
systematicName	ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins binds RAB11FIP3 dimer, RAB11A:GTP to form ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins:RAB11FIP3 dimer:RAB11A:GTP

Referrals

(hasEvent)	[Pathway:R-HSA-5620916] VxPx cargo-targeting to cilium
(precedingEvent)	[Reaction:R-HSA-5623513] ASAP1 stimulates GTPase activity of ARF4

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