ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Recruitment of ASAP1 to the TGN facilitates the subsequent recruitment of both RAB11A and the RAB11 effector protein FIP3 to the ciliary targeting complex. RAB11FIP3 functions as a homodimer and can bind simultaneously to RAB11 and ARF4 through its C-terminal region (Inoue et al, 2008; Mazelova et al, 2009; Wang et al, 2012; Shiba et al, 2006; Eathiraj et al, 2006; Schonteich et al, 2007). RAB11FIP3 also interacts with the BAR domain of ASAP1 and in this way may play a role in stimulating the ARF GAP activity of ASAP1, promoting the inactivation ARF4 and its subsequent dissociation from the TGN (Inoue et al, 2008; reviewed in Deretic, 2013).
Literature References
PubMed ID Title Journal Year
17628206 Molecular characterization of Rab11-FIP3 binding to ARF GTPases

Sentz, D, Pilli, M, Schonteich, E, Prekeris, R, Holmes, RK, Matern, HT, Junutula, JR, Simon, GC

Eur. J. Cell Biol. 2007
17030804 Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1

Wakatsuki, S, Kato, R, Shiba, T, Koga, H, Kawasaki, M, Nakayama, K, Shin, HW

Proc. Natl. Acad. Sci. U.S.A. 2006
17007872 Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes

Lambright, DG, Prekeris, R, Eathiraj, S, Mishra, A

J. Mol. Biol. 2006
18685082 Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome

Inoue, H, Prekeris, R, Randazzo, PA, Ha, VL

Mol. Biol. Cell 2008
19153612 Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4

Deretic, D, Schonteich, E, Inoue, H, Mazelova, J, Prekeris, R, Astuto-Gribble, L, Moritz, OL, Randazzo, PA, Tam, BM

EMBO J. 2009
22983554 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

Deretic, D, Morita, Y, Mazelova, J, Wang, J

EMBO J. 2012
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
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