Reactome | ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex

ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex

Stable Identifier

R-HSA-5620921

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex

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Recruitment of ASAP1 to the TGN facilitates the subsequent recruitment of both RAB11A and the RAB11 effector protein FIP3 to the ciliary targeting complex. RAB11FIP3 functions as a homodimer and can bind simultaneously to RAB11 and ARF4 through its C-terminal region (Inoue et al, 2008; Mazelova et al, 2009; Wang et al, 2012; Shiba et al, 2006; Eathiraj et al, 2006; Schonteich et al, 2007). RAB11FIP3 also interacts with the BAR domain of ASAP1 and in this way may play a role in stimulating the ARF GAP activity of ASAP1, promoting the inactivation ARF4 and its subsequent dissociation from the TGN (Inoue et al, 2008; reviewed in Deretic, 2013).

Literature References

PubMed ID	Title	Journal	Year
17628206	Molecular characterization of Rab11-FIP3 binding to ARF GTPases Schonteich, E, Pilli, M, Simon, GC, Matern, HT, Junutula, JR, Sentz, D, Holmes, RK, Prekeris, R	Eur. J. Cell Biol.	2007
17030804	Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1 Shiba, T, Koga, H, Shin, HW, Kawasaki, M, Kato, R, Nakayama, K, Wakatsuki, S	Proc. Natl. Acad. Sci. U.S.A.	2006
17007872	Structural basis for Rab11-mediated recruitment of FIP3 to recycling endosomes Eathiraj, S, Mishra, A, Prekeris, R, Lambright, DG	J. Mol. Biol.	2006
18685082	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome Inoue, H, Ha, VL, Prekeris, R, Randazzo, PA	Mol. Biol. Cell	2008
19153612	Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4 Mazelova, J, Astuto-Gribble, L, Inoue, H, Tam, BM, Schonteich, E, Prekeris, R, Moritz, OL, Randazzo, PA, Deretic, D	EMBO J.	2009
22983554	The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting Wang, J, Morita, Y, Mazelova, J, Deretic, D	EMBO J.	2012
23567335	Crosstalk of Arf and Rab GTPases en route to cilia Deretic, D	Small GTPases	2013