Reactome | Anchoring of the basal body to the plasma membrane

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Anchoring of the basal body to the plasma membrane Show undefined attributes

authored	[InstanceEdit:5620897] Rothfels, Karen, 2014-08-27
created	[InstanceEdit:5620913] Rothfels, Karen, 2014-08-27
dbId	5620912
displayName	Anchoring of the basal body to the plasma membrane
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-9975921] Assembly of the 9+0 primary cilium - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8935214] ciliary basal body-plasma membrane docking
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5626220] C2CD3 binds the mother centriole - Homo sapiens [Reaction:R-HSA-5626223] C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole - Homo sapiens [Reaction:R-HSA-5626228] The distal appendage proteins recruit TTBK2 - Homo sapiens [Reaction:R-HSA-5626699] MARK4 binds ODF2 in the centriole - Homo sapiens [Reaction:R-HSA-5626227] CP110 and CEP97 dissociate from the centriole - Homo sapiens [Reaction:R-HSA-5626681] Recruitment of transition zone proteins - Homo sapiens [Reaction:R-HSA-5638014] RAB11A:GTP-containing Golgi vesicles recruit RAB3IP - Homo sapiens [Reaction:R-HSA-5638009] CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body - Homo sapiens [Reaction:R-HSA-5617816] RAB3IP stimulates nucleotide exchange on RAB8A - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:5625323] The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization [LiteratureReference:5626633] Assembling a primary cilium [LiteratureReference:5626161] The centriole duplication cycle [LiteratureReference:5626134] Centrosomes and cilia in human disease [LiteratureReference:5626133] Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells [LiteratureReference:5626154] Reconstructions of centriole formation and ciliogenesis in mammalian lungs [LiteratureReference:5626162] The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking [LiteratureReference:5620911] Centriole distal appendages promote membrane docking, leading to cilia initiation [LiteratureReference:5617546] Ciliogenesis: building the cell's antenna [LiteratureReference:5626146] Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles [LiteratureReference:5626128] CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content [LiteratureReference:5620907] C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals [LiteratureReference:5620909] CCDC41 is required for ciliary vesicle docking to the mother centriole [LiteratureReference:5626125] A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition [LiteratureReference:5624018] Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? [LiteratureReference:5618171] Trafficking in and to the primary cilium [LiteratureReference:5626148] MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Anchoring of the basal body to the plasma membrane
orthologousEvent	[Pathway:R-SCE-5620912] Anchoring of the basal body to the plasma membrane - Saccharomyces cerevisiae [Pathway:R-SPO-5620912] Anchoring of the basal body to the plasma membrane - Schizosaccharomyces pombe [Pathway:R-CEL-5620912] Anchoring of the basal body to the plasma membrane - Caenorhabditis elegans [Pathway:R-GGA-5620912] Anchoring of the basal body to the plasma membrane - Gallus gallus [Pathway:R-XTR-5620912] Anchoring of the basal body to the plasma membrane - Xenopus tropicalis [Pathway:R-DRE-5620912] Anchoring of the basal body to the plasma membrane - Danio rerio [Pathway:R-SSC-5620912] Anchoring of the basal body to the plasma membrane - Sus scrofa [Pathway:R-BTA-5620912] Anchoring of the basal body to the plasma membrane - Bos taurus [Pathway:R-CFA-5620912] Anchoring of the basal body to the plasma membrane - Canis familiaris [Pathway:R-RNO-5620912] Anchoring of the basal body to the plasma membrane - Rattus norvegicus [Pathway:R-MMU-5620912] Anchoring of the basal body to the plasma membrane - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5620912
summation	[Summation:5626214] Cilium biogenesis is initiated by the docking of basal bodie...
updateTrackers	[UpdateTracker:9782597] Update Tracker - [Pathway:5620912] Anchoring of the basal body to the plasma membrane - v59:[modifyText, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782597] Update Tracker - [Pathway:5620912] Anchoring of the basal body to the plasma membrane - v59:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9975921] Assembly of the 9+0 primary cilium

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