Reactome | The distal appendage proteins recruit TTBK2

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The distal appendage proteins recruit TTBK2 Show undefined attributes

authored	[InstanceEdit:5625489] Rothfels, Karen, 2014-10-03
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5626226] Rothfels, Karen, 2014-10-08
dbId	5626228
displayName	The distal appendage proteins recruit TTBK2
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620912] Anchoring of the basal body to the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-5626699] MARK4 binds ODF2 in the centriole - Homo sapiens
input	[Complex:R-HSA-5626176] Centrosome:C2CD3:distal appendage proteins [cytosol] [EntityWithAccessionedSequence:R-HSA-5626168] TTBK2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5620907] C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals [LiteratureReference:5626139] Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole [LiteratureReference:5626165] The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis [LiteratureReference:5626443] CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease [LiteratureReference:5626438] Cep97 and CP110 suppress a cilia assembly program [LiteratureReference:5626635] Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis [LiteratureReference:5626445] Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11 [LiteratureReference:5626158] TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development [LiteratureReference:5626450] TTBK2 kinase: linking primary cilia and cerebellar ataxias
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	The distal appendage proteins recruit TTBK2
orthologousEvent	[Reaction:R-GGA-5626228] The distal appendage proteins recruit TTBK2 - Gallus gallus [Reaction:R-XTR-5626228] The distal appendage proteins recruit TTBK2 - Xenopus tropicalis [Reaction:R-SSC-5626228] The distal appendage proteins recruit TTBK2 - Sus scrofa [Reaction:R-BTA-5626228] The distal appendage proteins recruit TTBK2 - Bos taurus [Reaction:R-CFA-5626228] The distal appendage proteins recruit TTBK2 - Canis familiaris [Reaction:R-RNO-5626228] The distal appendage proteins recruit TTBK2 - Rattus norvegicus [Reaction:R-MMU-5626228] The distal appendage proteins recruit TTBK2 - Mus musculus
output	[Complex:R-HSA-5626178] Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol]
precedingEvent	[Reaction:R-HSA-5626223] C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole - Homo sapiens
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5626228
summation	[Summation:5626434] C2CD3 and the distal appendage protein CEP164 are required f...
systematicName	Centrosome:C2CD3:distal appendage proteins binds TTBK2 forming Centrosome:C2CD3:distal appendage proteins:TTBK2

Referrals

(precedingEvent)	[Reaction:R-HSA-5626699] MARK4 binds ODF2 in the centriole
(hasEvent)	[Pathway:R-HSA-5620912] Anchoring of the basal body to the plasma membrane