GLI3R binds the GLI1 promoter

Stable Identifier
R-HSA-5617408
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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GLI3R binds the GLI1 promoter
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GLI3R is a DNA-binding transcriptional repressor that recognizes consensus GLI sites 5'-GACCACCC-3' in the promoters of target genes (Kinzler and Vogelstein, 1990). DNA-binding is mediated through 5 C2H2 Kruppel zinc fingers in the N-terminal region of the protein, which remains intact after proteasome-mediated processing (reviewed in Hui and Angers, 2011). In the absence of Hh signaling, GLI3R has been shown to bind to the promoters of the GLI1 and GLI2 genes as assesed by ChIP and to repress gene expression (Hu et al, 2006).

Literature References
PubMed ID Title Journal Year
21801010 Gli proteins in development and disease

Hui, CC, Angers, S

Annu. Rev. Cell Dev. Biol. 2011
16396903 GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

Hu, MC, Mo, R, Bhella, S, Wilson, CW, Chuang, PT, Hui, CC, Rosenblum, ND

Development 2006
2105456 The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

Kinzler, KW, Vogelstein, B

Mol. Cell. Biol. 1990
Participants
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Output
Participant Of
hasEvent
Authored
Rothfels, K  (2014-07-23)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-08-07)