Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling

Stable Identifier
R-HSA-5612510
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, ciliary membrane
ReviewStatus
5/5
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Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling
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Expression of the PTCH1 gene is repressed in the absence of Hh signaling by GLI3R (Agren et al, 2004; Lee et al, 2010; Vokes et al, 2007; Vokes et al, 2008). GLI3R may exert its repression activity through the SKI-dependent recruitment of HDACs (Dai et al, 2002).
Literature References
PubMed ID Title Journal Year
12435627 Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3

Dai, P, Shinagawa, T, Nomura, T, Harada, J, Kaul, SC, Wadhwa, R, Khan, MM, Akimaru, H, Sasaki, H, Colmenares, C, Ishii, S

Genes Dev. 2002
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Vokes, SA, Ji, H, McCuine, S, Tenzen, T, Giles, S, Zhong, S, Longabaugh, WJ, Davidson, EH, Wong, WH, McMahon, AP

Development 2007
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Vokes, SA, Ji, H, Wong, WH, McMahon, AP

Genes Dev. 2008
15087129 Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site

Agren, M, Kogerman, P, Kleman, MI, Wessling, M, Toftgård, R

Gene 2004
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Lee, EY, Ji, H, Ouyang, Z, Zhou, B, Ma, W, Vokes, SA, McMahon, AP, Wong, WH, Scott, MP

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PTCH1 gene:GLI3R [nucleoplasm] (Homo sapiens)
Active Unit
GLI3R [nucleoplasm]
Authored
Rothfels, K  (2014-07-23)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
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