Reactome | KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules

KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules

Stable Identifier

R-HSA-5610733

Type

Reaction [binding]

Species

Homo sapiens

Compartment

ciliary tip

ReviewStatus

5/5

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KIF7 is recruited to the ciliary tip through interaction with axonemal microtubules

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KIF7, the human ortholog of Drosophila COS2, is a kinesin-4 motor protein that binds directly to the plus ends of axonemal microtubules and inhibits their growth in an ATP-dependent manner (He et al, 2014). KIF7 is required for the processing and activity of GLI in the absence of Hh signal, and KIF7 function depends on the primary cilium (Liem et al, 2009; Cheung et al, 2009; Endoh-Yamagami et al, 2009). KIF7 has been shown to bind to GLI3 and to SUFU and may act in part by promoting the transit of the GLI:SUFU complex through the primary cilium, which is required for GLI processing (Endoh-Yamagami et al, 2009; Maurya et al, 2013). How KIF7 itself is localized to the cilia tip is unknown, although localization depends on the KIF7 motor domain (Liem et al, 2009; He et al, 2014). KIF7 localization is further enhanced at the primary cilia tip in response to Hh signaling, as is also the case for GLI2, GLI3 and SUFU (He et al, 2014; Varjosalo et al, 2008; Haycraft et al, 2005; Wen et al, 2010; Qin et al, 2011; Tukachinsky et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
24339784	Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo Maurya, AK, Ben, J, Zhao, Z, Lee, RT, Niah, W, Ng, AS, Iyu, A, Yu, W, Elworthy, S, van Eeden, FJ, Ingham, PW	PLoS Genet.	2013
19666503	Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling Liem, KF, He, M, Ocbina, PJ, Anderson, KV	Proc. Natl. Acad. Sci. U.S.A.	2009
19592253	The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development Endoh-Yamagami, S, Evangelista, M, Wilson, D, Wen, X, Theunissen, JW, Phamluong, K, Davis, M, Scales, SJ, Solloway, MJ, de Sauvage, FJ, Peterson, AS	Curr. Biol.	2009
21209331	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components Qin, J, Lin, Y, Norman, RX, Ko, HW, Eggenschwiler, JT	Proc. Natl. Acad. Sci. U.S.A.	2011
16254602	Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function Haycraft, CJ, Banizs, B, Aydin-Son, Y, Zhang, Q, Michaud, EJ, Yoder, BK	PLoS Genet.	2005
19549984	The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling Cheung, HO, Zhang, X, Ribeiro, A, Mo, R, Makino, S, Puviindran, V, Law, KK, Briscoe, J, Hui, CC	Sci Signal	2009
20154143	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ	Mol. Cell. Biol.	2010
24952464	The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment He, M, Subramanian, R, Bangs, F, Omelchenko, T, Liem, KF, Kapoor, TM, Anderson, KV	Nat. Cell Biol.	2014
18455992	Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling Varjosalo, M, Björklund, M, Cheng, F, Syvänen, H, Kivioja, T, Kilpinen, S, Sun, Z, Kallioniemi, O, Stunnenberg, HG, He, WW, Ojala, P, Taipale, J	Cell	2008
20956384	A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes Tukachinsky, H, Lopez, LV, Salic, A	J. Cell Biol.	2010