Reactome | OCT3 mediates renal uptake of organic cations

OCT3 mediates renal uptake of organic cations

Stable Identifier

R-HSA-561072

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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OCT3 mediates renal uptake of organic cations

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The human gene SLC22A3 encodes organic cation transporter OCT3. It is mainly expressed in skeletal muscle, liver, placenta, kidney and heart, and to a lesser extent in brain. OCT3 is involved in the biliary excretion of cationic drugs. In CNS, ganglia and heart, OCT3 regulates the interstitial concentrations of monoamine neurotransmitters and cationic drugs. In placenta, OCT3 is responsible for the release of acetylcholine during nonneuronal cholinergic regulation (Grundemann D et al,1998; Wu X et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10966924	Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney Wu, X, Huang, W, Ganapathy, ME, Wang, H, Kekuda, R, Conway, SJ, Leibach, FH, Ganapathy, V	Am J Physiol Renal Physiol	2000
10196521	Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter Gründemann, D, Schechinger, B, Rappold, GA, Schömig, E	Nat Neurosci	1998