Reactome | OAT1,2,3 transport organic anions with antiport of dicarboxylic acids

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OAT1,2,3 transport organic anions with antiport of dicarboxylic acids Show undefined attributes

authored	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
catalystActivity	[CatalystActivity:561044] transmembrane transporter activity of OAT1,2,3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
crossReference	[DatabaseIdentifier:9958691] RHEA:76132 [DatabaseIdentifier:9958694] RHEA:76136
dbId	561041
displayName	OAT1,2,3 transport organic anions with antiport of dicarboxylic acids
edited	[InstanceEdit:561081] Jassal, Bijay, 2010-03-25
eventOf	[Pathway:R-HSA-561048] Organic anion transport by SLC22 transporters - Homo sapiens
input	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [DefinedSet:R-ALL-561049] OAT1,2,3 substrates [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:561080] Cloning of a human renal p-aminohippurate transporter, hROAT1 [LiteratureReference:561051] Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney [LiteratureReference:561245] Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C [LiteratureReference:561248] Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]) [LiteratureReference:561060] Isolation of a family of organic anion transporters from human liver and kidney [LiteratureReference:561045] Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux [LiteratureReference:561040] Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3) [LiteratureReference:9947196] Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function [LiteratureReference:9947198] Urate transport via human PAH transporter hOAT1 and its gene structure
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	OAT1,2,3 transport organic anions with antiport of dicarboxylic acids
orthologousEvent	[Reaction:R-CEL-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Caenorhabditis elegans [Reaction:R-DME-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Drosophila melanogaster [Reaction:R-GGA-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Gallus gallus [Reaction:R-XTR-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Xenopus tropicalis [Reaction:R-DRE-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Danio rerio [Reaction:R-SSC-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Sus scrofa [Reaction:R-BTA-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Bos taurus [Reaction:R-CFA-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Canis familiaris [Reaction:R-RNO-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Rattus norvegicus [Reaction:R-MMU-561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - Mus musculus
output	[SimpleEntity:R-ALL-561075] 2OG [extracellular region] [DefinedSet:R-ALL-561078] OAT1,2,3 substrates [cytosol]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-561041
summation	[Summation:561050] The human gene SLC22A6 encodes organic anion transporter1 (O...
updateTrackers	[UpdateTracker:9953622] Update Tracker - [Reaction:561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - v93:[modifyText, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9953622] Update Tracker - [Reaction:561041] OAT1,2,3 transport organic anions with antiport of dicarboxylic acids - v93:[modifyText, removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-561048] Organic anion transport by SLC22 transporters

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