Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
FailedReaction
>
Entries
Defective GALE does not epimerise UDP-Gal to UDP-Glc
Show undefined attributes
Go to Details
authored
[InstanceEdit:5610019] Jassal, Bijay, 2014-07-21
catalystActivity
[CatalystActivity:9631875] UDP-glucose 4-epimerase activity of GALE V94M:GALE V94M:NAD+:NAD+ [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5610019] Jassal, Bijay, 2014-07-21
crossReference
[DatabaseIdentifier:12020875] Mondo:0018116
dbId
5610036
disease
[Disease:5610005] galactosemia
displayName
Defective GALE does not epimerise UDP-Gal to UDP-Glc
edited
[InstanceEdit:5610019] Jassal, Bijay, 2014-07-21
entityFunctionalStatus
[EntityFunctionalStatus:5609998] loss_of_function of GALE V94M:GALE V94M:NAD+:NAD+ [cytosol]
eventOf
[Pathway:R-HSA-5609977] Defective GALE causes EDG - Homo sapiens
input
[SimpleEntity:R-ALL-29452] UDP-Gal [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5610017] Identification and characterization of a mutation, in the human UDP-galactose-4-epimerase gene, associated with generalized epimerase-deficiency galactosemia
[LiteratureReference:5678667] Epimerase-deficiency galactosemia is not a binary condition
[LiteratureReference:5678643] Altered cofactor binding affects stability and activity of human UDP-galactose 4'-epimerase: implications for type III galactosemia
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Defective GALE does not epimerise UDP-Gal to UDP-Glc
normalReaction
[Reaction:R-HSA-70369] GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc
releaseDate
2015-06-17
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5678669] Timson, David J, 2015-02-25
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5610036
summation
[Summation:5610034] Cytosolic UDP galactose 4 epimerase (GALE) catalyses the int...
updateTrackers
[UpdateTracker:9778225] Update Tracker - [FailedReaction:5610036] Defective GALE does not epimerise UDP-Gal to UDP-Glc - v68:[addCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9778225] Update Tracker - [FailedReaction:5610036] Defective GALE does not epimerise UDP-Gal to UDP-Glc - v68:[addCatalystActivity]
(hasEvent)
[Pathway:R-HSA-5609977] Defective GALE causes EDG
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text