Reactome | SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol

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SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10482220] secondary active transmembrane transporter activity of SLC22A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10482226
displayName	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
eventOf	[Pathway:R-SSC-549127] SLC-mediated transport of organic cations - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-549261] ERGT [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol
output	[SimpleEntity:R-ALL-549260] ERGT [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[NegativeRegulation:10482227] Negative regulation by 'RUNX1 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-549241
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-549127] SLC-mediated transport of organic cations
(inferredTo)	[Reaction:R-HSA-549241] SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol

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