Reactome | SP-A/SP-D:TLR4:MD2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5432863] Shamovsky, Veronica, 2014-05-12
dbId	5432881
displayName	SP-A/SP-D:TLR4:MD2 [plasma membrane]
hasComponent	[DefinedSet:R-HSA-391108] SFTPA oligomer, SFTPD oligomer [extracellular region] [Complex:R-HSA-166050] TLR4:LY96 [plasma membrane]
inDisease	false
includedLocation	[Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - Mus musculus [Complex:R-RNO-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - Canis familiaris [Complex:R-BTA-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - Bos taurus [Complex:R-SSC-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - Sus scrofa [Complex:R-GGA-5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - Gallus gallus
isChimeric	false
literatureReference	[LiteratureReference:5432773] Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization
maxDepth	6
modified	[InstanceEdit:8871616] Weiser, JD
name	SP-A/SP-D:TLR4:MD2
producedByEvent	[Reaction:R-HSA-5432852] SFTPA/SFTPD binds TLR4:LY96 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5432881
updateTrackers	[UpdateTracker:9896850] Update Tracker - [Complex:5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - v61:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9896850] Update Tracker - [Complex:5432881] SP-A/SP-D:TLR4:MD2 [plasma membrane] - v61:[updateContainedComponent]
(output)	[Reaction:R-HSA-5432852] SFTPA/SFTPD binds TLR4:LY96