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SP-A/SP-D:TLR4:MD2 [plasma membrane]
Stable Identifier
R-HSA-5432881
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Regulation of TLR by endogenous ligand (Homo sapiens)
SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)
SP-A/SP-D:TLR4:MD2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16754682
Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization
Mitsuzawa, H
,
Himi, T
,
Sano, H
,
Yamada, C
,
Kuroki, Y
,
Nishitani, C
,
Shimizu, T
J. Biol. Chem.
2006
Participants
components
SFTPA oligomer, SFTPD oligomer [extracellular region]
(Homo sapiens)
TLR4:LY96 [plasma membrane]
(Homo sapiens)
Participates
as an output of
SFTPA/SFTPD binds TLR4:LY96 (Homo sapiens)
Inferred To
SP-A/SP-D:TLR4:MD2 [plasma membrane]
(Bos taurus)
SP-A/SP-D:TLR4:MD2 [plasma membrane]
(Canis familiaris)
SP-A/SP-D:TLR4:MD2 [plasma membrane]
(Gallus gallus)
SP-A/SP-D:TLR4:MD2 [plasma membrane]
(Mus musculus)
SP-A/SP-D:TLR4:MD2 [plasma membrane]
(Rattus norvegicus)
SP-A/SP-D:TLR4:MD2 [plasma membrane]
(Sus scrofa)
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