Reactome | SFTPA/SFTPD binds TLR2:TLR1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10055051
displayName	SFTPA/SFTPD binds TLR2:TLR1
eventOf	[Pathway:R-MMU-5686938] Regulation of TLR by endogenous ligand - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Homo sapiens
input	[DefinedSet:R-MMU-391108] SFTPA oligomer, SFTPD oligomer [extracellular region] [Complex:R-MMU-168946] TLR1:TLR2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SFTPA/SFTPD binds TLR2:TLR1
output	[Complex:R-MMU-5432872] SFTPA/SFTPD:TLR2:TLR1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5432814
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-5686938] Regulation of TLR by endogenous ligand
(inferredTo)	[Reaction:R-HSA-5432814] SFTPA/SFTPD binds TLR2:TLR1

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